RE: [NMusers] multiple dose with unequal dosing intervals

Why do you have II=48 when ADDL=0 (no additional dose)?Should not be
II=0?
Serge Guzy
 

________________________________

From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com]
On Behalf Of Yuyan Jin
Sent: Tuesday, May 27, 2008 7:53 AM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] multiple dose with unequal dosing intervals


 
Hi All,
I am trying to analyze a multiple dose oral PK data (with unequal dosing
intervals) using NONMEM. second dose is given 48 hrs after the first
dose and after that the drug is given on 12 hr dosing interval over 14
days. There are 8 sampling points available in first 48 h and then one
trough sample is available after 7 days, and following last dose, 8 data
points are available for next 24 h.
 
the following is a representative of my data set
 
#ID TIME DV AMT ADDL II MDV
102 0 0 60 0 48 1
102 0.5 205 0 0 0 0
102 1 305 0 0 0 0
102 2 283 0 0 0 0
102 4 134 0 0 0 0
102 6 78.8 0 0 0 0
102 8 51.5 0 0 0 0
102 12 17.6 0 0 0 0
102 24 2.16 0 0 0 0
102 48 0 60 30 12 1
102 192 704 0 0 0 0
102 360 585 0 0 0 0
102 360.5 782 0 0 0 0
102 361 1070 0 0 0 0
102 362 1460 0 0 0 0
102 364 1270 0 0 0 0
102 366 965 0 0 0 0
102 368 652 0 0 0 0
102 372 433 0 0 0 0

my model is not runing due to data record error message, Can anybody
please help me setting up the data file?
Any inputs will be appreciated.
 
Thanks a lot,
Yuyan
graduate student
 

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Received on Tue May 27 2008 - 12:22:38 EDT