[NMusers] Sparse (pediatric) and rich (adult) data

Hi,

I am working on a pop PK model to estimate PK parameters in pediatric and =
adult patients. Pediatric study (n=20, age <6 yrs) has fewer samples (3) =
per subject whereas the adult study (n=50, median age 20 yrs) has 12 =
samples per subject. A two-compartment model best describes the data for =
each data set. Although a two-compartment model best describes the =
combined data, the individual parameter estimates in pediatric population =
are different compared to those obtained using with pediatric data alone. =
Note that the parameter estimates in adults were not significantly altered =
with either combined or adult data alone. Body weight is the only =
covariate included in the model with allometric exponents fixed to 0.75 on =
CL and 1 on V1.
 
I would like to hear your thoughts on this and any suggestions on how to =
proceed with modeling combined data from pediatric and adult studies.
 
Regards,
- Chandra



Received on Wed May 28 2008 - 11:47:10 EDT