RE: [NMusers] Sparse (pediatric) and rich (adult) data

Hi Chandra

If you want some ideas on how to proceed on modelling with combined adult
and paediatric data, you may want to refer to the following posters:

Cella et al., PAGE 16 (2007) Abstr 1203
[www.page-meeting.org/?abstract=1203]

Cella et al., ACOP 2008 Abstr 46
[http://www.mosaicnj.org/acop/pdfs/46_DellaPasqua.pdf]

 

Regards

Massimo

_______________________________________

Massimo Cella

LACDR / Pharmacology, room 636

Gorleaus Laboratories

Einsteinweg 55 2333 CC Leiden

The Netherlands

Tel : ++31 71 527 6207

Email: m.cella_at_lacdr.leidenuniv.nl

 

 

 

  _____

From: owner-nmusers_at_globomaxnm.com [mailto:owner-nmusers_at_globomaxnm.com] On
Behalf Of Chandrasekhar Udata
Sent: Wednesday, May 28, 2008 5:47 PM
To: nmusers_at_globomaxnm.com
Subject: [NMusers] Sparse (pediatric) and rich (adult) data

 

Hi,


I am working on a pop PK model to estimate PK parameters in pediatric and
adult patients. Pediatric study (n=20, age <6 yrs) has fewer samples (3) per
subject whereas the adult study (n=50, median age 20 yrs) has 12 samples per
subject. A two-compartment model best describes the data for each data set.
Although a two-compartment model best describes the combined data, the
individual parameter estimates in pediatric population are different
compared to those obtained using with pediatric data alone. Note that the
parameter estimates in adults were not significantly altered with either
combined or adult data alone. Body weight is the only covariate included in
the model with allometric exponents fixed to 0.75 on CL and 1 on V1.

 

I would like to hear your thoughts on this and any suggestions on how to
proceed with modeling combined data from pediatric and adult studies.

 

Regards,

- Chandra



Received on Thu May 29 2008 - 10:54:18 EDT