[NMusers] covariate-based dose prediction

Dear nmusers,

Could anyone tell me how i can predict the required dose of a drug at steady state based on final sequential PK/PD estimates from NONMEM.
If I assume for example a target PD value of INR is 2.5. VKORC1 (and CYP2C9 polymorphism and AGE) affect PD (and PK) profiles.

Thanks in advance
Best Regards

khaled



      

Received on Thu Apr 30 2009 - 05:37:42 EDT