Date: Wed, 20 Jan 2010 08:47:02 +0100
Dear Colleague,
Please find information about two upcoming courses arranged by the =
Swedish Academy of Pharmaceutical Sciences.
Introduction to Quantitative Pharmacology and PK/PD for Drug Discovery & =
Development Scientists, Munich, Germany, September 2-3, 2010
This course aims to give the delegates confidence and encouragement to =
have a go at PKPD and to build relationships between bioscience, DMPK, =
medicinal chemistry and related scientific disciplines. The programme is =
comprised of lectures and afternoon group exercises.
Course objectives
* To raise awareness amongst bioscience, medicinal chemistry and =
clinical scientists of what kinetic-dynamic (PKPD) methods can offer
* To raise awareness of the individual steps that makes up the =
dose-plasma-distribution-binding-turnover- response process
* To raise awareness of experimental design. What investment has to be =
done early and late in discovery?
* To build a case for the assessment of the first time in man dose
* To provide theory and methods of in vivo PKPD data
Who should attend?
Bioscience, safety, medicinal chemistry and clinical scientists, =
statisticians, pharmacokineticists, pharmacologists etc.
Topics
* PK from a PD point of view
* PK half-life vs. half-life of response
* The apparent disconnection between PK and PD
* Emax-models and their difficulties if maximum response is lacking
* Effect compartment models in (distribution-rate limited) responses
* Turnover models in (turnover-rate limited) responses
* Receptor on/off binding models in (binding-rate limited) responses
* Scaling pharmacodynamics and PK properties to man
* Practical experimental design of PD studies
* PKPD assessment at milestone decisions
For further information, please visit our website: =
www.lakemedelsakademin.se/munich
The 17th Intermediate Workshop on PK/PD Data Analysis: A Hands-on Course =
Using WinNonlin, Rome, Italy, September 26-30, 2010
Course outline
Morning sessions consist of lectures dealing with choice of weights, =
goodness-of-fit, interpretation of computer output, experimental design =
and discrimination between rival models. Afternoon sessions are devoted =
to applying the methods discussed in the lectures to actual data, using =
WinNonlin. One afternoon session will be given as an introduction for =
participants with no, or very little, experience with WinNonlin. The =
participants work on their own laptops during the hands-on sessions.
Who should attend?
This workshop is intended for individuals engaged in the pharmaceutical =
industry, regulatory agencies, contract research companies and =
universities and for others who want to learn the aspects of model =
fitting. Previous participants have been toxicologists, kineticists, =
bioanalytical chemists, pharmacologists, clinical pharmacologists, =
anaesthesiologists, clinical research assistants and scientists from =
academia and regulatory agencies. Participants should have a background =
in pharmacokinetics but those with limited experience would also =
benefit. The number of participants is limited.
Topics
*Introduction and overview
*Assessment of goodness of fit
*Pharmacodynamic issues
*Design of experiments
*Comparison of models
For further information, please visit: www.lakemedelsakademin.se/17th
With kind regards,
Annica Flodin, Projektadministratör/Project Administrator
Läkemedelsakademin
Box 1136, 111 81 Stockholm, Sweden
Besöksadress: Wallingatan 26A
Tel. 08-723 50 40; Fax 08-20 55 11
E-mail: annica.flodin_at_lakemedelsakademin.se =
<mailto:annica.flodin_at_lakemedelsakademin.se>
Hemsida: www.lakemedelsakademin.se <http://www.lakemedelsakademin.se/>
