[NMusers] input function

Dear all,

 

I wonder how to deal with different infusion schedules. In my dataset the 2=
4 hour infusions were given in two different regimens:

One was to infuse 10% of the dose for 5 minutes followed by an 23:55 h infu=
sion of the rest of the dose. The other was to infuse the 10% in the beginn=
ing for one hour followed by an 23 h infusion of the remaining 90% of the d=
ose. 4 hour infusions were given in only one infusion.

I set up the data file as follows:

The dose time is at 10 to put the pre-dose PD-measurement in front.

 

ID TIME RATE AMT DOSE DUR MD=
V PD-MDV DV PD-DV

1 0 0 0 0 =
    0 1 0 . [value]

1 10 [AMT/DUR] [0.1*DOSE] [value] 0.083 1 =
   1 . .

1 10.083 [AMT/DUR] [0.9*DOSE] [value] 23.92 1 =
1 . .

1 14 0 0 [value] =
0 0 0 [value] .

...

 

For the model I use an ADVAN3 subroutine with TRANS4.

Alternatively I tried to put this in a $PRED routine but with two record fo=
r each rate and two records for each duration, which lead to different resu=
lts.

 

Did I manage the data right and how can I see my Amount in the compartment =
if I don't use differential equations?

 

 

 

-----------------------------

Hauke Rühs

Apotheker

Pharmazeutisches Institut

- Klinische Pharmazie -

An der Immenburg 4

53121 Bonn

 

Tel: + 49-(0)228 73-5781

Fax: + 49-(0)228 73-9757

 

 <http://www.klinische-pharmazie.info/> www.klinische-pharmazie.info

 






Received on Fri Jan 29 2010 - 12:06:07 EST