From: Janet Wade <jwade@pharsight.com>

Subject: NONMEM users repository - (pkpd.icon.palo-alto.med.va.gov)

Date: Tue, 14 Aug 2001 13:08:03 -0700

 

This link has been down for ages, is this site still available to us?

Janet

 

-----Original Message-----

From: Joern Loetsch [mailto:j.loetsch@em.uni-frankfurt.de]

Sent: den 14 augusti 2001 21:19

To: bvatul; nmusers@c255.ucsf.edu

Cc: Venkatesh Atul Bhattaram

Subject: Re: Conversion of micro constants to macro constants

 

 

There is an Excel spread sheet doing this, developed by Dr. Steven Shafer,

Stanford. It can be downloaded from

http://pkpd.icon.palo-alto.med.va.gov/

<http://pkpd.icon.palo-alto.med.va.gov/>

 

However, the link was down right now.

Jorn Lotsch

_______________________________________________________

Jorn Lotsch, MD

pharmazentrum frankfurt, Department of Clinical Pharmacology

Johann Wolfgang Geothe-University Hospital

Theodor-Stern-Kai 7

D-60590 Frankfurt

Germany

Phone: +49-69-6301-4589

Fax: +49-69-6301-7636

 

*****

 

From: "Bachman, William" <bachmanw@globomax.com>

Subject: RE: NONMEM users repository - (pkdp.icon.palo-alto.med.va.gov)

Date: Wed, 15 Aug 2001 08:40:44 -0400

 

The VA has taken pkdp.icon.palo-alto.med.va.gov off line while they recover

from a massive infection of the Code Red II virus. The site may not have

been hit, but they took all systems running IIS off line. The hope is that

it will be back up next week.

 

nmconsult@globomax.com

GloboMax LLC

7250 Parkway Drive, Suite 430

Hanover, MD 21076

Voice: (410) 782-2205

FAX: (410) 712-0737

 

-----Original Message-----

From: Johan Areberg [mailto:JOAR@Lundbeck.com]

Sent: Wednesday, August 15, 2001 8:27 AM

To: 'nmconsult@c255.ucsf.edu'

Subject: NONMEM users respiratory

 

Dear NONMEM group,

 

I was trying to download NMSEE5.FOR from the NONMEM users repository site

(pkdp.icon.palo-alto.med.va.gov), but couldn't find the site. Is the adress

still valid?

 

Best regards

 

Johan Areberg, Ph. D.

H. Lundbeck A/S

Pharmacokinetics/-Dynamics

2500 Valby

Denmark

 

******

 

From: Steve Shafer <sshafer@pharsight.com>

Subject: RE: [Fwd: Re: Conversion of micro constants to macro constants]

Date: Wed, 15 Aug 2001 21:19:51 -0700

 

Dear Lew:

 

Yep. The VA was hit with a massive Code Red II infection, which brought down

many critical servers. The pkpd server was shut off while they go through

and disinfect/reactivate the servers. I hope to have it back up by the end

of the week.

 

In the mean time time, the spreadsheet convert.xls is attached. This does

the conversions readily, and should be self-explanatory.

 

Best regards,

 

Steve

-----------------------

Steven L. Shafer, M.D.

VP, Information Products

Pharsight Corporation

Phone: 650 314-3859

Mobile: 650 704-0558

FAX: 650 314-3810

 

-----Original Message-----

From: LSheiner [mailto:lewis@c255.ucsf.edu]

Sent: Tuesday, August 14, 2001 1:02 PM

To: Steve Shafer

Subject: [Fwd: Re: Conversion of micro constants to macro constants]

 

 

And indeed it is .... More gov't interference?

Best,

L.

 

-------- Original Message --------

 

Subject: Re: Conversion of micro constants to macro constants

Date: Tue, 14 Aug 2001 21:18:46 +0200

From: "Joern Loetsch" <j.loetsch@em.uni-frankfurt.de>

To: "bvatul" <bvatul@ufl.edu>, <nmusers@c255.ucsf.edu>

CC: "Venkatesh Atul Bhattaram" <bvatul@ufl.edu>

References: <001001c124eb$0b6ea680$b117e380@134.ufl.edu>

 

There is an Excel spread sheet doing this, developed by Dr. Steven Shafer,

Stanford. It can be downloaded from http://pkpd.icon.palo-alto.med.va.gov/

<http://pkpd.icon.palo-alto.med.va.gov/> However, the link was down right

now.Jorn Lotsch_______________________________________________________

Jorn Lotsch, MD

pharmazentrum frankfurt, Department of Clinical Pharmacology

Johann Wolfgang Geothe-University Hospital

Theodor-Stern-Kai 7

D-60590 Frankfurt

Germany

Phone: +49-69-6301-4589

Fax: +49-69-6301-7636

 

******

 

From: Steve Shafer <sshafer@pharsight.com>

Subject: pkpd web site

Date: Sat, 18 Aug 2001 10:43:45 -0700

 

Dear Colleagues:

 

The Repository at pkpd.icon.palo-alto.med.va.gov is back on line.

 

I apologize for the service interruption. The VA hosts this for free (a

plus) but the site is therefore under their control (a minus). The VA was

hit with a massive Code Red II infection, and they pulled all servers off

line while they cleaned it up. Yesterday I determined that the repository

server was NOT infected, so I put it back on line (after installing all the

recent Win NT and IIS patches).

 

Several people noted that the service has been intermittent this past year.

To the best of my knowledge, there have only been two other interruptions:

 

The server was done about 6 weeks ago. This was caused by the VA shutting it

down in response to a congressional mandate that all government servers had

to state the official government policy on use of personal information. It

took me a few days to change the home page to make it compliant.

 

About 6 months ago the server was down because the VA rewired the internal

network, and forgot to physically plug my office into it.

 

Despite my running the server on a Win NT box using IIS, the server itself

has been completely reliable for the 6 years it has been running. I don't

recall a single computer crash or IIS failure.

 

Hopefully the repository will again be a reliable resource for the PK/PD

community. Please don't hesitate to contact me with questions or

suggestions.

 

Thanks,

 

Steve Shafer