From: "Yungwei Hsu"
Subject: [NMusers] Model Validation Date: Tue, 19 Mar 2002 13:24:20 -0500 Dear all, I have a 3-compartment nonlinear model based on only 7 subjects' data. Could somebody tell me the best way to do model validation? I had tried Jackknife but failed because the standard error became too big when I took out any subject's data to run NONMEM. And I don't think bootstrapping will work. By the way, what is the minimal subjects number to do bootstrapping? Thanks, Yung-Wei Hsu MD Research Fellow Duke University Medical Center ******* From: "Joern Loetsch" Subject: Re: [NMusers] Model Validation Date: Tue, 19 Mar 2002 21:04:05 +0100 1 What about getting independent data from somewhere and look how good your model predicts them? Jorn ******* From: "Piotrovskij, Vladimir [PRDBE]" Subject: RE: [NMusers] Model Validation Date: Wed, 20 Mar 2002 09:16:16 +0100 I wonder how many random effects do you have in the model? I don't think you can estimate more than one or two having the data from 7 subjects only. Best regards, Vladimir *******