From: "Sale, Mark" <ms93267@GlaxoWellcome.com>
Subject: NONMEM conc-reponse analysis for depression
Date: Fri, 5 Oct 2001 13:21:10 -0400

Dear users,
Is anyone aware of a successful NONMEM analysis for depression, using a
Hamm-D score or similar. We are interested in describing a
concentration-response relationship for an anti-depressant drug using phase
III data. Any comments?
Thanks

Mark

 

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From: "Gibiansky, Ekaterina" <gibianskye@globomax.com>
Subject: RE: NONMEM conc-reponse analysis for depression
Date: Fri, 5 Oct 2001 14:13:56 -0400

Mark,

after trying to find an answer to the same question for antipsychotics, and
after an unsuccessful PopPK/PD (I found no PK/PD or Dose-response
relationship, though there was a difference from placebo) for an
antipsychotic drug, I am not too optimistic. Luc Balant would be a right
person to ask the question. I can also fax you a couple pages of references
from the paper "Use of dose/concentration response data in psychotropic drug
development". This was a presentation at the 1997 COST B1 meeting "Clinical
pharmacology in psychiatry: finding the right dose of psychotropic drugs".
Luc Balant was one of the editors.

Katya