From:Xiao, Alan alan_xiao@merck.com
Subject: [NMusers] Literature on PK/PD modeling with two data points (baseline and end of study duration) 
Date: Fri, April 2, 2004 4:36 pm

Hello, 

Does anyone know any publications about population PK/PD modeling with two
data points (PD endpoint) per subject only (one baseline value and one
measurement at the end of the study). Ideally, I could collect a paper on
theoretical research and one on case studies.

Someone asked me to show literature that population PK/PD approach could be
applied to this scenario and both interindividual and intraindividual
variabilities are potentially identifiable (if you are the author, please be
prepared to be questioned - not from me - no kidding).


Or if you have a better way to convince him (than a publication), please let
me know.

Your help is really appreciated. 


Have a nice weekend.


Alan

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