From: "Zhang, Xiaoping {PDC5~Nutley}" 
Subject: [NMusers] what is behind $Simulation
Date: Tue, 23 Apr 2002 12:58:36 -0400

Dear NONMEM users: 
Can someone tell me how NONMEM finds the random numbers for two variables
for $SIMULATION? For example in following control stream, standard deviation
for both V and CL are considered by NONMEM for simulation.    

$THETA 1.5    ;CL 
$THETA 5.4    ;V 

$OMEGA 
.0961 
 2.3 
  
$SIGMA (0 FIXED) 

$SIMULATION (1275 NEW) ONLYSIMULATION 

One can also fix one ETA and only simulate another one. 

How NONMEM works for two variable ETAs? 

Your though is gratefully appreciated. Thank you. 

Best Regards, 
Xiaoping Zhang, Ph.D. 
Clinical Pharmacologist 
Department of PDMP 
Building 85/2N21, 
Hoffmann-La Roche Inc. 
340 Kingsland St., Nutley, NJ USA 07110 
Phone (973) 235-6584; Fax (973) 235-5635