From: Bonate, Peter
Subject: NONMEM testing set
Date: Thu, 17 Jan 2002 07:57:15 -0600

Dear All,
One of the things that has always interested me is the consistency in
NONMEM results across platforms and the inter-modeler reliability at coming
up with similar models.  I have a data set that I can put together and share
with the world.  The data set is a data rich data set from about 16 volunteers
with about 20 samples per patient.  There is about a dozen covariates.  It's a
relatively small data set.  I am wondering if there is any interest among modelers
to independently model this data set, compare the results across modelers and
platforms, and then publish the results.

All results will be confidential.  What we will be examining is comparison of models
in terms of consistency, numerical consistency, and the time it takes to develop the model.
If you are interested in participating let me know.  If we have enough people interested we
can move this idea forward.  I'm thinking that in terms of timelines we would have the models
developed by the end of the year, model comparisons done by 1Q03, and submit for
publication 2Q03 or 3Q03.

One thing that would need to be worked out is authorship.  If you have 
any ideas how to handle this please let me know.

Lastly, DO NOT RESPOND TO THIS EMAIL BY REPLYING.  REPLY TO MY EMAIL AD
DRESS BELOW.

Thanks,

pete

Peter L. Bonate, PhD
Director, Pharmacokinetics
ILEX Oncology, Inc
4545 Horizon Hill Blvd
San Antonio, TX  78229
phone: 210-949-8662
fax: 210-949-8487
email: pbonate@ilexonc.com