From: "Daniel Corrado" daniel_corrado@yahoo.com
Subject: [NMusers] AUC computation using noncompartmental method 
Date: Fri, April 1, 2005 10:46 am

I am trying to compute AUC from a sparse data set after oral dosing. The problem
is that the drug is metabolized by multiple pathways and is extremely variable.
On top of that it is an extended release formulation. Three plasma sample are
drawn around the projected Tmax. I have never used NonMem for non-compartmental
analyses. My question hence is: If a compartmental model cannot be fit to the
data, is their a way to determine the AUC? 


Thanks,

Dan
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