From: "jiang zhigang" jiangzhigangchn@hotmail.com
Subject: [NMusers] How could I determine which thetan(n=1,2,3...) will be put to K or CL?
Date: Tue, 08 Aug 2006 12:24:51 +0800
Hi,all,
I'm a beginner of NONMEM!
I was confused how to determine the theta(1) or theta(2) or theta(n)(n=1,2,3...) is K or V?
For example,
CL=THETA(1) K=THETA(1) CL=THETA(1)
K= THETA(2) CL= THETA(2) V= THETA(2)
V= CL/K V= CL/K K= CL/V
S1=V S1=V S1=V
CODE1 CODE2 CODE3 What differences are there between the 3 code above ?
How could I determine which thetan(n=1,2,3...) will be put to K?
Thanks!
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From: Nick Holford <.holford@auckland.ac.nz
Subject: Re: [NMusers] How could I determine which thetan(n=1,2,3...) will be put to K or CL?
Date: Tue, 08 Aug 2006 18:15:43 +1200
Jiang,
I am afraid I have a lot of difficulty understanding your questions.
However, all your codes are correct. It is your personal choice which one you prefer.
I prefer CODE3 because I think that CL and V are independent parameters and K is a dependent parameter.
Nick
--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556
http://www.health.auckland.ac.nz/pharmacology/staff/nholford/
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From: "Bachman, William (MYD)" bachmanw@iconus.com
Subject: Re: [NMusers] How could I determine which thetan(n=1,2,3...) will be put to K or CL?
Date: Tue, 8 Aug 2006 08:06:06 -0400
The theta numbering is detemined by you. NONMEM only expects the to see the names of parameters
based on the ADVAN and TRANS that you choose. e.g., for ADVAN1 TRANS2, NONMEM requires code
for CL and V. The numerical order of these parameters, is up to you. Which parameterization
you choose (CL/V or K/V) is also up to you.
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