From: PRANEET VALODIA <PRANEET@PHARMACY.UWC.AC.ZA>

Subject: FOCE

Date: 13 Aug 1998 10:49:07 -0400

Dear Dr Beal

I will be grateful if you could supply me with the following information:

(1) a reference/s for the FOCE method (excluding NONMEM manuals).

(2) when using the FOCE method the % CV for linear Clearance of phenytoin increased from 46% to 96% when compared with the FO method. Can this be explained?

I would forward to your response.

Thanks

P. Valodia PhD

University of the Western Cape

Private Bag X17

Bellville

7535

SOUTH AFRICA

fax: 27-21-9593407

email: praneet@uwc.ac.za