From: tgordi@buffalo.edu
Subject: [NMusers] Simulating large number of samples
Date: 8/26/2003 9:54 AM

Dear all,

I am trying to perform a simulation of both PK and PD using NONMEM. When
simulating an extensive sampling (1 individual, around 90 PK and 90 PD
time-points within 7 days) I get the following message:

0TOT NO. OF PRED-DEFINED RECS IN BUFFER 6 IS LESS THAN NO. OF DATA RECS
WITH SOME INDIVIDUAL SEE INSTALLATION GUIDE

Cutting down the file to 20 PK and 20 PD time-points (within 2 days)
results in successful simulation. It seems to me that there is some
default setting that does not allow for too many data-points to be
simulated. Is there any remedy for this that does not involve cutting
down the number of generated data-points?

Thanks!

Toufigh Gordi

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From: sliao@pharmaxresearch.com
Subject: RE: [NMusers] Simulating large number of samples
Date: 8/26/2003 11:39 AM 

Hi Toufigh,

Please go to this UserNet Archive to fix this problem.

http://www.cognigencorp.com/nonmem/nm/96aug162001.html

Sam

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From: tgordi@buffalo.edu
Subject: RE: [NMusers] Simulating large number of samples
Date: 8/26/2003 12:28 PM

Dear Sam,

Thank you for the tip. I have done as instructed and it works now.

This is the second time I encounter problems related to the low default
numbers in NONMEM. Although fixing them has been quite easy (once the instructions
have been provided), I am in general very reluctant to change the codes myself.
Are there any particular reasons why the default values are not increased in the
newer copies of NONMEM?

Toufigh


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