**From: jsabo@bi-pharm.com
**

Fellow NONMEMer's -

Rather than include variables to account for conmed use, gender, formulation, fasted or fed, etc., etc., etc. in a NONMEM data file, I had tried coding in the $PK block. However, NMTRAN gave me an error that pointed to DIMCNS being too small (this was not changed from the default of 50 when I compiled NMTRAN and NONMEM). Rather than changing source code and recompiling, it appears that I can accomplish what I want to do using verbatim code, but I could not find a specific example. In any event, I gave the following code a try and it seemed to work. Did I code correctly? Even though this code seemed straight-forward, I'm just a bit concerned about the warning in the guide that says "verbatim code should only be used by those who understand well how generated subroutines are structured".

Thanks,

John Sabo

Drug Metabolism and Pharmacokinetics

Boehringer Ingelheim Pharmaceuticals, Inc.

$PK

;Effect of conmed on CL

;0 =3D - conmed

;1 =3D + conmed

CONM=3D0

" IF(PTNO.EQ.100) CONM=3D1

" IF(PTNO.EQ.101) CONM=3D1

" IF(PTNO.EQ.102) CONM=3D1

" IF(PTNO.EQ.103) CONM=3D1

" IF(PTNO.EQ.104) CONM=3D1

.

.

.

" IF(PTNO.EQ.195) CONM=3D1

" IF(PTNO.EQ.196) CONM=3D1

" IF(PTNO.EQ.197) CONM=3D1

" IF(PTNO.EQ.198) CONM=3D1

" IF(PTNO.EQ.199) CONM=3D1

=20

TVKA =3D THETA(1)

TVCL =3D THETA(2) * (1 + THETA(3) * CONM) =20

=20

TVV =3D THETA(4)