From: Sam Liao - sliao@pharmaxresearch.com
Subject: [NMusers] CLS routines called in $DES to obtain the individual's plasma concentration predictions
Date: 2/18/2004 9:26 PM

Dear nonmem users:
 
Does anyone know where to get the codes that was mentioned in
Dr. Kyungsoo Park's e-mail in 1966 (see below)? 
 
I can no longer find it in the NONMEM repository.
 
Best regards,
Sam Liao
 
=================================================================== 

    From kyungsoo Wed Oct 16 12:23:59 1996
    Subject: new CLS

    Dear NONMEM users:

    Since the CLS program was released last month, several NONMEM users
	have raised a question that if it can also be used in $DES for PK/PD
	modeling, as well as in $PRED for PK modeling.

    The program has been REVISED in that way. That is, the CLS subroutines
	can now be called in $DES to obtain the individual's plasma concentration
	predictions at the effect measurement times. In more details, the new
	version can be used for:

    1. PK modeling
    1.1. Single-dose
    1.2. Steady-state

    2. PK/PD modeling
    2.1. Single-dose: Effect is indirectly linked to plasma concentration. (e.g., effect compartment)
    2.2. Single-dose: Effect is directly linked to plasma concentration.
    2.3. Steady-state: Effect is indirectly linked to plasma concentration.

    The files for the new version are available in NONMEM.DIR/CLS.DIR
	(same directory as before) by anonymous ftp from the NONMEM repository
	or from the NONMEM users network:

    ftp pkpd.icon.palo-alto.med.va.gov
    http://pkpd.icon.palo-alto.med.va.gov

    Thanks.

    Kyungsoo Park, Davide Verotta, and Lewis B. Sheiner
    University of California, San Francisco
    Room C255, Box 0626
    San Francisco, CA 94143
    E-mail: kyungsoo@c255.ucsf.edu 
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From: "Bachman, William (MYD)" - bachmanw@iconus.com
Subject: RE: [NMusers] CLS routines called in $DES to obtain the individua l's plasma concentration predictions
Date: 2/19/2004 8:53 AM

The NONMEM repository was moved to GloboMax a couple of years ago:

ftp://ftp.globomaxnm.com/Public/nonmem/

see the continuous_linear_spline folder



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Hanover, MD 21076 
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