From:"Rajeev Menon"   
Subject:[NMusers] lag time  
Date:Wed, February 20, 2002 4:27 pm  



I am having a problem with the control stream for nonmem. The model that best
fits the data is a 2 compartment model with  lag time. The nonemem model that I
am using is


> $PROBLEM  POPULATION DATA FOR FLURBIPROFEN
> $INPUT ID TIME DV AMT
> $DATA  NMRFLUR.csv IGNORE=C
> $SUBROUTINES  ADVAN4  TRANS1
>
> $PK
>   TVKA=THETA(1)
>   TVK=THETA(2)
>   TVK23=THETA(3)
>   TVK32=THETA(4)
>   TVV=THETA(5)
>   TVALAG1=THETA(6)
>
>   KA=TVKA*(1 + ETA(1))
>   K=TVK*(1 + ETA(2))
>   K23=TVK23*(1 + ETA(3))
>   K32=TVK32*(1 + ETA(4))
>   V=TVV*(1 + ETA(5))
>   ALAG2=TVALAG1*(1+ETA(6))
>   S1=V
>
> $ERROR
> Y=F*(1+ERR(1))
>
> $THETA  (0,0.61)  (0,0.30) (0,0.086) (0,0.157) (0,8755) (0, 0.25)
>
> $OMEGA 0.22 0.09 0.74 0.22 0.79 0.5
> $SIGMA 0.002 0.2
> $ESTIMATION MAXEVAL=9999 PRINT=5 NOABORT
> $COV
> $TABLE ID TIME AMT FILE= 1NMRFLUR.tab NOPRINT
>

I cannot get the program to run as it says the Lag statement TVALAG1 has more
than 6 characters and is an error. How can I get around this.

Thanks,

Rajeev

 


*******

From:"Bachman, William"   
Subject:RE: [NMusers] lag time  
Date:Wed, February 20, 2002 4:38 pm  

call it "TLAG1" 
  
are you sure you want to use ALAG2? 
  
(The lag from the depot to the central compartment is ALAG1). 
  
  
Bill 

*******

From:  "Bachman, William"    
Subject:  RE: [NMusers] lag time [2]
Date:  Wed, February 20, 2002 4:45 pm   
 
 

Rajeev 

one other point - if your observations are in the central compartment,
you will want to define S2 (not S1)

Bill
 
 

*******

From:"Williams, Gene M"   
Subject:RE: [NMusers] lag time
Date:Wed, February 20, 2002 4:45 pm  

Change "TVALAG1" to any non-reserved name of 5 characters or less. 
  
"TVLAG1" is a name you might like... 


*******


From:"Williams, Gene M"   
Subject:RE: [NMusers] lag time  
Date:Wed, February 20, 2002 4:47 pm  

Make that TVLG1. 



*******


From:"Atul"   
Subject:Re: [NMusers] lag time  
Date:Wed, February 20, 2002 5:02 pm  

Hello Rajeev 
  
Please change it to TLAG1. I think this should not cause any problem.
You can always check by simulation prior to your actual runs. 
  
  
Venkatesh Atul Bhattaram
Post-doctoral Fellow
University of Florida