From: alison@c255.ucsf.EDU (ABoeckmann)
Subject: DIGITAL Visual Fortran 5.0
Date: 18 Jul 1997 12:55:37 -0400

To NONMEM users with PC's and DIGITAL Visual Fortran 5.0:

In May I sent email suggesting DIGITAL Visual Fortran 5.0 as an alternative to the discontinued Microsoft Fortran PowerStation. I said:

"The command that invokes Fortran 5.0 is "df" and it has a totally new set of options. However, for the sake of customers who are moving from Powerstation, it can also be invoked as "fl32", and the old options are recognized. (Old command; new compiler!) It detects which command was used, and has different defaults for "df" vs. "fl32", but recognizes both sets of options."

It turns out that there is a known bug when the "fl32" command is used (DIGITAL's "PowerStation I/O compatibility mode"). This bug does not exist when the "df" command is used (DIGITAL's "native DIGITAL Fortran I/O"). It does not exist with Microsoft PowerStation Fortran's fl32 command.

When NM-TRAN is processing a relatively large file (e.g., the size of the PHENO file on the release medium, approx. 745 lines), the bug causes NM-TRAN to fail with the message

AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.
THE CHARACTERS IN ERROR ARE:

FWORK
36 ERROR HAS OCCURED WHILE CREATING REQUIRED FILE.

A similar error occurs in NONMEM with large files.

The workaround is simple.

With DIGITAL Visual Fortran 5.0, all compiles of NONMEM, PREDPP, and NM-TRAN should be done using the "df" command rather than "fl32".

-----------------------------------------------
Note to people who received the Installation Notes memo dated May 13, 1997:

In every case, simply change fl32 to df in the lines marked with (DF).

For NONMEM and PREDPP:

df /c /fpe:0 /optimize:1 *.for

For NM-TRAN:

df *.for

For NONMEM executable, use either of the below depending if the nmfe.bat file is used or not used:

df /fpe:0 /optimize:1 fsubs.for @link.lnk \nmiv\nm\*.obj
df /fpe:0 /optimize:1 fsubs.for @adv2tr1.lnk \nmiv\nm\*.obj

-----------------------------------------------

Thanks to Sanjeev Kumar of the Univ. of British Columbia for bringing this problem to my attention, and for his help in solving it.

Alison Boeckmann

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From: NISHIHARA SHIGEKI <sn777@hp.okayama-u.ac.jp>
Subject: NONMEM and DIGITAL Visual Fortran 5.0
Date: 2 Aug 1997 06:27:13 -0400

To NONMEM users

I attempt to NONMEM under WindowsNT4.0,using the DIGITAL Visual Fortran 5.0.
Does anyone have experience with this combination?
Please send me information.

Thanks.

Shigeki Nishihara
Department of Hospital Pharmacy
Okayama University Medical School
email:sn777@hp.okayama-u.ac.jp

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From: alison@c255.ucsf.EDU (ABoeckmann)
Subject: NONMEM and DIGITAL Visual Fortran 5.0
Date: 5 Aug 1997 18:44:16 -0400

To: nmusers, sn777@hp.okayama-u.ac.jp

Shigeki Nishihara asked about NONMEM under WindowsNT4.0,using the DIGITAL Visual Fortran 5.0.

We now have both operating systems installed at the NONMEM Project Group and I've tested NONMEM installation under both. The DIGITAL compiler can be used with both Windows 95 and Windows NT 4.0. There is no difference in NONMEM installation and use.

Simply follow the recommendations in the memo

INSTALLATION NOTES FOR NONMEM VERSION IV UNDER DOS OR MICROSOFT WINDOWS USING MICROSOFT FORTRAN POWERSTATION OR DIGITAL VISUAL FORTRAN 5.0

Use the command fl32 when compiling the SEP program.

E.g., fl32 sep.for

Use the command "df" when compiling all other programs (NONMEM, PREDPP, NMTRAN, and FSUBS).

We recommend for NONMEM and PREDPP and FSUBS:

df /c /fpe:0 /optimize:1 *.for

We recommend for NMTRAN:

df *.for

(A note of explanation: With fl32, DIGITAL's "PowerStation I/O compatibility mode" is used, which is best for SEP. With df, DIGITAL's "native DIGITAL Fortran I/O" is used. This is best for the other programs.)

If anyone has any trouble with DIGITAL Visual Fortran 5.0 under Windows NT, please let me know.

If you would like the latest version of the memo (July 16, 1997), send email to me and I'll send it to you via email.

Alison Boeckmann, NONMEM Project Group.

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From: "Chris H. Takimoto, M.D., Ph.D." <ctakim@helix.nih.gov>
Subject: Digital Visual Fortran and NONMEM
Date: 18 Aug 1997 19:46:12 -0400

For all you highly exprienced NONMEM users:

I'm a bit bleary-eyed from struggling with a re-installation of NONMEM on a Pentium PC running windows 95. The old system used Windows 3.1 and Microsoft Powerstation 1.0a and worked well, but we recently upgraded to Windows 95. As many are aware, Microsoft no longer sells Fortran Powerstation 4.0 for Windows 95, instead it has been licensed to Digital. I have thus far successfully loaded NM-Tran and gotten that part of the program to work, but I'm stuck in linking and reading NM files in the "NM" folder. Some of the files dhave not seemed to compile correctly and can't be read by NONMEM.

Have any NONMEM IV users had experience using Digital Fortran 5.0. I've read Bill Bachman's very helpful guidelines on this subject, but he didn't seem to have any problems getting the program loaded and running. My specific question is are there problmes with this complier that others have run into and should I try to get a second hand copy of MS Powerstation 4.0 for Windows 95 and try that instead. Thanks in advance.

Chris Takimoto
ctakim@helix.nih.gov
National Cancer Institute

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From: alison@c255.ucsf.EDU (ABoeckmann)
Subject: Re: Digital Visual Fortran and NONMEM
Date: 19 Aug 1997 12:49:58 -0400

To: Chris Takimoto

At the NONMEM Project Group, we've had no problem with NONMEM IV under Digital Visual Fortran, if it is compiled correctly. I'll send you a copy of our latest memo - if you still have trouble after following the suggestions in the memo, let me know. Please send exact copies of any compiler or run time error messages.

Alison Boeckmann