From: Jiun-Li Jang <jjang@voicenet.com>

Subject: Error message 72

Date: Tue, 31 Jul 2001 22:59:29 -0400

 

Dear all,

 

I am a new NM user, I started my first NM study recently and encountered

a problem (floating error-overflow; Error message 72). I need your help

to direct me how to resolve this problem. I have tried to change omega

and sigma values, comma out the ALAG1 and ETA3. I have also tried to

change the boundary conditions (enlarged or decreased). The error

message was always shown, then the program was stopped. Very few times

I could get the table in the directory but not output file if I was not

kicked out in the begining. I realized that the number of subjects may

not be enough to conduct population PK analysis, it was just a try, if

the model works, then I'll add more subjects. Please find the attached

control file and data file, I thank you in advance for taking your time

and effort to teach me.

 

J.J.

 

*******

 

From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com>

Subject: RE: Error message 72

Date: Wed, 1 Aug 2001 10:11:40 +0200

 

Jiun-Li,

 

I think you have a typo in your control stream. ALAG1 should be as follows:

 

ALAG1=THETA(6)*EXP(ETA(3))

 

After correction, convergence is achieved (see the output attached).

 

 

Best regards,

Vladimir

 

------------------------------------------------------------------------

 

Vladimir Piotrovsky, Ph.D.

Research Fellow

Global Clinical Pharmacokinetics and Clinical Pharmacology (ext. 5463)

Janssen Research Foundation

B-2340 Beerse

Belgium

Email: vpiotrov@janbe.jnj.com