From: "Joost DeJongh" <j.dejong@CHEM.LeidenUniv.nl>
Date: Mon, 7 Jun 1999 11:51:17 +0000
Subject: implementation of cosine function

Hello,
I recently ran into a problem trying to use a cosine-based model for cyclic hormonal levels. In the $PRED block, I defined a cosine model for population data as follows:
...
A1=(DAY-TMAX)*6.28/CYCLE
"A2=COS(A1)
...

DAY is the x-variable (time)
This way, the model cannot obtain an ETA on TMAX.

Any help would be greatly appreciated.

Joost DeJongh, Ph.D.

Leiden Experts in Advanced Pharmacokinetics & Pharmacodynamics (LeapP)
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