From: Youngjin Moon ymoon2@acsu.buffalo.edu
Subject: [NMusers] ADVAN6..
Date: Wed, 28 Jun 2006 11:27:00 -0400

Dear All,

Hello.. I am very beginner of NONMEM.. 

I am trying to change a code which previous employee made. It is PK-PD 
model. Two compartment PK model with two biomarkers. He used ADVAN6 
TOL=3 as $SUBROUTINE. CMT1= depot, CMT2=plasma, 
CMT3=peripheral, CMT4= biomarkerA, CMT5=biomarkerB. 
And he used
     
     S2=V2
     S4=1
     S5=1

     F4=bioA			;DEFINING INITIAL CONDITION FOR CMT=4
     F5=bioB			;DEFINING INITIAL CONDITION FOR CMT=5

In my case I need to change to one compartment model.
I learned in class that with ADVAN1-4 CMT number is designated (like 
CMT 2= central in ADVAN2). But I don't have ADVAN6 information.

My question is.. 
If I don't need peripheral compartment, can I use CMT1= depot, 
CMT2=plasma, CMT3= biomarkerA, CMT4=biomarkerB, and change to 
     S2=V2
     S3=1
     S4=1

     F3=bioA			;DEFINING INITIAL CONDITION FOR CMT=3
     F4=bioB			;DEFINING INITIAL CONDITION FOR CMT=4



Or, do I have to keep those number without CMT 3? 

Thanks a lot!!!

Youngjin

Youngjin Moon
544 Hochstetter Hall 
Department of Pharmaceutical Sciences 
School of Pharmacy and Pharmaceutical Sciences 
University at Buffalo 
State University of New York 
Buffalo, NY 14260-1200 
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From: Elodie.Plan@sanofi-aventis.com
Subject: RE: [NMusers] ADVAN6..
Date: Wed, 28 Jun 2006 18:53:08 +0200

Dear Yougjin,

I am also a very beginner...
but it seems to me that your solution is right!
CMT1= depot, CMT2=plasma, CMT3= biomarkerA, CMT4=biomarkerB, yes.

so you are going to have got 1 central compartment + a depot, 
so as parameters: ka between the two, CL from the central, and V for the central,
that s why I don't think you can write V2.

the scale seemed to be on the peripheral compartment which you have removed,
you can either write only S3=1 S4=1, either add S1=V.

about the subroutine, advan 6 includes a peripheral compartment, 
advan 2 (trans 2) might be better adapted,
but because of biomarkers, I don't know...

Good luck, hope you'll get other advices!


Elodie Plan
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