From: hzding <hzding@21cn.com>
Subject: negative objective function values
Date: Mon, 19 Mar 2001 10:19:31 +0800

Dear Sir or Madam,

I am a doctor student majoring pharmacokinetics. Now I am busy in preparing my doctor degree thesis. When I estimate population paremeters with NONMEM,

the objective function is always negative number. I don't the reason. Would you like to help me? Thank you very much for you kindness.

Sinecely yours

hzding
03/20/2000
hzding@21cn.com


*****


From: "Bachman, William" <bachmanw@globomax.com>
Subject: RE: negative objective function values
Date: Mon, 19 Mar 2001 08:26:00 -0500

The objective function consists of the sum of two terms. The first is a sum of squares term, which will always be postitive. The second term is a log of variances term which can, of course, be a negative. If the second terms predominates, the objective function will be a negative number.

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