From: "Bachman, William" 
Subject: [NMusers] NONMEM Tips #15 - March 19, 2003 - NONMEM V using Open Watcom 1.0 Fortran for Windows
Date:Wed, 19 Mar 2003 11:48:49 -0500

NONMEM Tips #15 - March 19, 2003 - NONMEM V using Open Watcom 1.0 Fortran
for Windows:

A free FORTRAN compiler for the Microsoft Windows environment is available
from Open Watcom.  Open Watcom is a joint effort between SciTech Software
Inc, SybaseŽ, and the Open Source development community to maintain and
enhance the Sybase Watcom C/C++ and Fortran compiler products.


http://www.openwatcom.org/


A new setup file, setup4.bat, for installing NONMEM V with Open Watcom 1.0
for Windows has been created.  An additional file, NMow1.bat, which is a
template for the nmfe5.bat file for Open Watcom 1.0, is also required. Both
files can be downloaded from the GloboMax ftp site at:


ftp://ftp.globomaxnm.com/Public/nonmem/watcom/


Setup4.bat can implemented in either of two ways:

1. Copy setup4.bat and NMow1.bat to COPIES of your NONMEM distribution
diskettes 1 and 3.  Then run setup4.bat with arguments from the command line
at the appropriate floppy drive directory, e.g. from a:
a:> setup4 a c nmv wfl386 y lib

OR:

2. Create a new directory on your hard-drive e.g., c:\nmow1.  Copy
setup4.bat, NMow1.bat and all the files within the main installation
directory of an existing NONMEM directory, e.g. from c:\nmv, to the new
directory. (DO NOT copy the subdirectories from c:\nmv)  Then run setup4.bat
with arguments from the command line at the appropriate new directory, e.g.
from c:\nmow1. e.g.:
c:\nmow1> setup4 a c nmow1 wfl386 y lib


setup4.bat is used in the same manner as the original "setup.bat" file.
Arguments must be specified from the DOS command prompt, e.g.:

setup4 a c nmv wfl386 y lib

where
a is the diskette drive
c is the hard drive
nmv is the install directory
wfl386 is the compiler command (for Open Watcom Fortran)
y is yes for optimization
lib is the name of the link program (or, in this case, the library program)

(setup4.bat can also be used with Intel 7.0, Compaq/Digital, GNU G77, or MS
Powerstation 4.0, by substituting ifl, df, g77 or fl32 for wfl386 in the
above
command line).

The critical changes to the file related to:

a. compiler optimizations:

/ox  - basically all optimizations (see Open Watcom documentation)
/6   - CPU target optimized for Pentium Pro
/fp6 - floating point options optimized for Pentium Pro

b. *SIZES files copied to *SIZES.for

The NONMEM files that must be modified during setup are:

1. BLKDAT.FOR: change "con" to "nul"
Note: Iterations will not be output to the console.

2. FLU.FOR:
comment out "CALL COMMITQQ(I)"
Note: Flushing the buffer was not required for Open Watcom 1.0 on Windows
2000 Professional.
If required with other OS's, substitute the following for "CALL
COMMITQQ(I)":

      INCLUDE 'FSUBLIB.FI'
      INTEGER ISTAT
      ISTAT=FLUSHUNIT(I)

Evaluation of Open Watcom with NONMEM V level 1.1 gave comparable results to
the Intel 7.0, Compaq/Digital and g77 Fortran compilers for CONTROL3,
CONTROL4, CONTROL5, CONTROL6, CONTROL7 and a library of control streams
consisting of all the standard ADVAN's and TRANS's (models and
parameterizations) available in NONMEM V.  Test operating system was Windows
2000 Professional.

References:
1. NONMEM Users Guide Part III, pp.14,18,24,32,35,39,49,53,59,66,75,79,131.
2. Personal communication from Nick Holford: 3-18-2003 and information
obtained by searching for "watcom" 
available from the NONMEM archive:
(
http://www.cognigencorp.com/nonmem/sitesearch/index.html
)


Previous tips may be found in the NONMEM Repository@GloboMax: 


ftp://ftp.globomaxnm.com/Public/nonmem/tips/


See the index.txt file for a listing of previous tips.

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