From: "Sreenivasa Rao Vanapalli" <svanapal@blue.weeg.uiowa.edu>

Subject: Error Messgae

Date: Wed, 16 May 2001 09:19:57 -0500

I'm getting this message: Please someone interpret this for me.

MONITORING OF SEARCH:

0PRED EXIT CODE = 1

0INDIVIDUAL NO. 7 ID= .21000000E+02 (WITHIN-INDIVIDUAL) DATA REC NO.

22

THETA=

3.00E-01 8.00E-01 1.00E-01 1.00E-02 1.30E+01 1.00E-03 2.00E+02

1.00E+00 5.00E+00 1.50E-01

NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE.

NO. OF REQUIRED SIGNIFICANT DIGITS IN SOLUTION VECTOR TO DIFFERENTIAL

EQUATIONS, 5, MAY BE TOO LARGE.

0PROGRAM TERMINATED BY OBJ

MESSAGE ISSUED FROM ESTIMATION STEP

AT INITIAL OBJ. FUNCTION EVALUATION

1THERE ARE ERROR MESSAGES IN FILE PRDERR

Regards

Sreenivasa Rao Vanapalli, Ph.D,

Janssen Postdoctoral Research Scholar,

S411 PHAR, College of Pharmacy,

University of Iowa, Iowa City, IA-52242

319-353-5157 (Office)

319-337-2687 (Home)

*****

From: "Bachman, William" <bachmanw@globomax.com>

Subject: RE: Error Messgae -> NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE

Date: Wed, 16 May 2001 10:38:24 -0400

NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE means, well, it's having problems with the numerical integration!

You basically have a few choices:

1. Change the relative tolerance, TOL, from 5 to a number requiring fewer significant figures, e.g. 3

2. Try a different numerical integration algorithm, e.g. if you are using ADVAN6, try ADVAN8 or ADVAN9.

3. Your model is too complex, make it simpler.

Bill

*****

Subject: RE: Error Messgae

Date: Wed, 16 May 2001 15:55:53 +0100

Dear Sreenivasa,

Try to reduce TOL from 5 to 3 or use ADVAN8 or ADVAN9.

Regards,

Medeval Ltd

Skelton House

Manchester Science Park

Lloyd Street North

Manchester, UK

Tel: xx-44-161-226 6525 (Ext 295)