From:sadrai@sina.tums.ac.ir
Subject:[NMusers] Asking about equation describing plasma concentration of metabolite after oral administration
Date:Sat, 18 May 2002 12:18:06 +0430

Hello All,
Is there any one who knows equation used for description of plasma 
concentration of a metabolite after oral administration of the main drug?
Thanks,
Sima Sadray

*******

From:David Bourne 
Subject:[NMusers] Re: Asking about equation describing plasma concentration of metabolite after oral administration
Date:Sat, 18 May 2002 19:26:50 -0500

You could use the page http://www.boomer.org/c/p3/c07/c0707.html to 
generate the Laplace of the required equation and then use the 
fingerprint method (http://www.boomer.org/c/p3/c07/c0706.html) to get 
the integrated equation for the amount; dividing by Vm to get the 
equation for metabolite concentration. [For a one compartment model the 
roots are -kel, -ka, and -kmu]
;-)

David