From: "Daniel Yuan" <dzyuan@hotmail.com>
To: nmusers@c255.ucsf.edu
Subject: References on NONMEM application
Date: Wed, 19 May 1999 06:54:16 PDT

Does anybody know of publications/references where NONMEM has been used to

model drug PK in a peripheral compartment (e.g, synovial fluid) where there

is the issue of relating plasma population PK to the peripheral compartment?


Your help is much appreciated

Zhi Yuan, PhD
Div Clin Pharma
Uniformed Services University
Bethesda, MD 20814

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Date: Wed, 19 May 1999 16:20:28 -0500 (EDT)
From: Jogarao Gobburu 301-594-5661 FAX 301480-8329 <GOBBURUJ@cder.fda.gov>
Subject: Re: References on NONMEM application

Previously, NONMEM has been used to model plasma and CSF concentrations in "Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children. Br J Clin Pharmacol. 1998 Sep;46(3):237-43". This work was done by Anderson, Nick Holford and others. The authors have used a link compartment approach (with a partition coefficient) in relating the plasma and the csf compartments.

With regards,
Joga

Joga Gobburu
Pharmacometrics,
CDER, FDA

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Date: Fri, 21 May 1999 13:01:35 +0200
From: "acpphos" <acpphos@wanadoo.fr>
Subject: Re: References on NONMEM application

Here's one :

M.Tod,C.Pobel,V.Le Gros,K.Louchahi, P.Petitjean,N.Brion. A population pharmacokinetic study of alminoprofen penetration into synovial fluid. Biopharm.Drug Dispos., 1995, 16, 627-634.

Christian Pobel

C.POBEL SERVICE DE PHARMACIE CLINIQUE
CENTRE HOSPITALIER BP326 17108 SAINTES CEDEX
T 33 5 46 92 76 20
F 33 5 46 92 77 14
christian.pobel@wanadoo.fr