From: BellyGom@aol.com
Subject: [NMusers] Error message: NO MORE THAN  20 ADDITIONAL AND/OR LAGGED DOSE RECORDS ~
Date: 11/5/2003 10:38 AM

Dear All,

I have the following error message and hope that someone can help me to
resolve this problem (without deleting datapoints.!.)

NO MORE THAN  20 ADDITIONAL AND/OR LAGGED DOSE RECORDS ACTIVE AT ONE TIME   

I got rather common screen output (DOS) as follows:

WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
(WARNING 2) NM_TRAN INFERS THAT THE DATA ARE POPULATION
1 file(s) copied.
Starting nonmem execution ...
ITERATIONS ARE NOT OUTPUT TO CONSOLE FOR G77
1 file(s) copied.

The following is the content of FREPORT

NM-TRAN VERSION III LEVEL 1.1 
SUBROUTINES FROM THE PREDPP LIBRARY:
PRED     PREDI    CHECK    SADVAN   ADVAN6   SSS0     TRANS1   INFN   
DVERK1   FCN1   
GENERATED DP SUBROUTINES:
PK       ERROR    MODEL    TOL      DES    
NONMEM SUBROUTINES: ALL

many thanks in advance,
In-Sun
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From: "Bachman, William (MYD)" bachmanw@iconus.com
Subject: RE: [NMusers] Error message: NO MORE THAN 20 ADDITIONAL AND/OR LA GGED DOSE RECORDS ~
Date: 11/5/2003 11:02 AM

This is a message that suggests that something is probably wrong
with your model, not the data.
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From: BellyGom@aol.com
Subject: Subject: [NMusers] Error message: NO MORE THAN  20 ADDITIONAL AND/OR LAGGED DOSE RECORDS ~
Date: 11/5/2003 12:12 PM

Dear Dr. Bachman,

Thanks for your interest in the problem; do you have some idea what might be
wrong with the model? It actually runs okay(??) after eliminating subjects
causing the message at the bottom; the original data size is approx. 6000*20
and after eliminating those subjects, it is approx. 4000*20.

I indeed have many dose/lagged dose records per subject since I have duplicated
the multiple dosing events for comp. 1 (central)  4 times, for  4 additional
lagged compartments; the amounts in the four comp.s characterises the drug effect.
And samples are often Very sparse. I will be more than happy to provide further
information to resolve this matter.... (I just don't know which is relevant...)

Many many thanks,
In-Sun

MONITORING OF SEARCH:

0PRED EXIT CODE = 1                                                                                                                 
0INDIVIDUAL NO.   10   ID=0.16000000E+02   (WITHIN-INDIVIDUAL) DATA REC NO. 130                                                     
THETA=                                                                                                                             
  1.44E+02   2.40E+02   1.00E+01   1.11E+01   3.16E+02   2.04E+00   2.05E+02   5.48E-01   1.00E+00   1.20E+00                       
  2.91E-01   4.36E+01                                                                                                               
NO MORE THAN  20 ADDITIONAL AND/OR LAGGED DOSE RECORDS MAY BE ACTIVE AT ONE TIME                                                   
0PROGRAM TERMINATED BY OBJ
MESSAGE ISSUED FROM ESTIMATION STEP
AT INITIAL OBJ. FUNCTION EVALUATION
1THERE ARE ERROR MESSAGES IN FILE PRDERR
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From: "Bachman, William (MYD)" bachmanw@iconus.com
Subject: RE: [NMusers] Error message: NO MORE THAN 20 ADDITIONAL AND/OR LA GGED DOSE RECORDS ~
Date: 11/5/2003 1:09 PM

While IT IS possible to "legitimately" have too many add'l or lagged doses, in
our experience this message usually represents a problem with the model which
requires the model to modified.  Since your model runs with the "offending
subject(s)" removed, your model may actually be OK.  It's not possible for me
to tell you what is problematic with these subjects without seeing the
full model and the data.  I'm not really sure why you are giving lagged
doses to the effect compartments.  Can you elaborate?
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From: Dr. Vicente G. Casabo  vicente.casabo@uv.es
Subject: RE: [NMusers] Error message: NO MORE THAN 20 ADDITIONAL AND/OR LA GGED DOSE RECORDS ~
Date:  11/06/2003 18:11:15 GMT Standard Time

I read the question, IMHO the problem is not the number of additional or
lagged doses, the problem is the  actual number of dose records, which
are delayed or contain addl. This is the number of rows of this kind of
data in data file. Try reduce the nuber of dose records at fixed times,
converting the records in additional doses included on the same dose
record that first, at each compartment. AMT and II and ADDL can approximate
as possible the actual schedule of administration or incorporation into
compartment, if no can be exact.  
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From: BellyGom@aol.com
Subject: Subject: [NMusers] Error message: NO MORE THAN  20 ADDITIONAL AND/OR LAGGED DOSE RECORDS ~
Date: 11/6/2003 1:47 PM

Dear Professor Casabo,

It is very good to hear from you; hope that you and Ricardo are doing fine.

Thank you so much for your suggestion; so I should try to minimise the
dataset by reducing the number of addled/lagged dose events in the
dataset whereever possible, via ADDL, AMT and II?

Best wishes,
In-Sun
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