From: Rajesh.Krishna@aventis.com
Subject: [NMusers] Applications of PK Principles in Drug Development / TOC
Date: 11/19/2003 12:33 PM


Colleagues:

A number of you requested the table of contents for the above named book.
For everybody's benefit, please find below more information on the chapters.

If you have any questions, please feel free to contact me directly.

Regards,
Rajesh

http://www.wkap.nl/prod/b/0-306-47766-1
Applications of Pharmacokinetic Principles in Drug Development  
Edited by Rajesh Krishna, Ph.D., F.C.P. 
Aventis Pharmaceuticals Inc., Bridgewater, NJ, USA 

This book presents a collection of articles that represent individual and
expert perspectives in both preclinical and clinical development, including
case studies on real-life examples of successful drugs that add value to the
pharmacokinetic principles learned and applied. Unlike many existing books
that focus on pharmacokinetic theory, the current book emphasizes application
of pharmacokinetic principles in new drug development.
Kluwer Academic/Plenum Publishers.  Hardbound, ISBN 0-306-47766-1, October
2003, 556 pp.
EUR 112.50 / USD 125.00 / GBP 86.25

Table of Contents:  

1. Efficient and Effective Drug Development; W.A. Colburn, G. Heath.  
2. Bioanalytical Methods: Challenges and Opportunities in Drug Development;
M.L. Powell, S.E. Unger.  
3. Prediciting Human Oral Bioavalibility using In Silico Models; L. X. Yu, et
al. 
4. Drug Metabolism in Preclinical Development; M.W. Sinz. 
5. Interspecies Scaling; T. Lavé, et al. 
6. Human Drug Absorption Studies in Early Development; D.V. Prior, et al. 
7. Food-Drug Interactions: Drug Development Considerations; D. Fleisher, L.
Reynolds. 
8. Global Regulatory and Biopharmaceutics Strategies in New Drug Development:
Biowaivers; E. Gupta, E. Yamashita. 
9. Special Population Studies in Clinical Development: Pharmacokinetic
Considerations; J.M. Kovarik. 
10. Drug-Drug Interactions; S.M. Huang. 
11. Pharmacokinetic/Pharmacodynamic Modeling in Drug Development; S.
Rohatagi, et al. 
12. Population Pharmacokinetic and Pharmacodynamic Modeling; R. Jelliffe, et
al. 
13. Role of Preclinical Metabolism and Pharmacokinetics in the Development of
Celecoxib; S.K. Paulson, T.J. Maziasz. 
14. The Role of Clinical Pharmacology and of Pharmacokinetics in the
Development of Alendronate - A Bone Resorption Inhibitor; A.G. Porras, B.J.
Gertz. 
15. Optimizing Individualized Dosage Regimens of Potentially Toxic Drugs;
R.W. Jelliffe, et al. 
Appendix. 
Index. 
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