From: "=?big5?B?YmVhdXR5ZW15?=" <beautyemy@sinamail.com>
Subject: [NMusers] Michaelis Menten kinetics
Date: Thu, 29 Nov 2001 11:38:51 +0800

Dear NONMEM users:
I have a question about Michaelis Menten Kinetics. According to NONMEM Users Guide-Part VIII p.321, the unit of Km can be amount. Is that reasonable?
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From: Steve_Charnick@vpharm.com
Subject: Re: [NMusers] Michaelis Menten kinetics
Date: Thu, 29 Nov 2001 07:45:16 -0500

I am unware of a physiological reason for which Km could have units such as an amount. However, it is possible that NONMEM allows this for a situation in which the parameters are transformed in some way. I hope this helps.

Steven

 

 

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From: David_Bourne <david@boomer.org>
Subject: Re: [NMusers] Michaelis Menten kinetics
Date: Thu, 29 Nov 2001 10:26:23 -0600

>Dear NONMEM users:
>I have a question about Michaelis Menten Kinetics. According to
>NONMEM Users Guide-Part VIII p.321, the unit of Km can be amount. Is
>that reasonable?

It is probably because NONMEM uses drug amount in mg internally when
calculating differential equation solutions. Thus the equation is...

dX/dt = - Vm*X/(Km + X) [or maybe even dC/dt = - Vm*X/V*(Km + X)] Km
needs to be in mg to match the units for X.

David Bourne

 

 

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From: "Emily" <r89451003@ms89.ntu.edu.tw>
Subject: Re: [NMusers] Michaelis Menten kinetics
Date: Fri, 30 Nov 2001 09:44:39 +0800

Dear NONMEM users:
If we use amount to be the unit of Km, how do we interpretate the results??