From: tgordi@buffalo.edu
Subject: [NMusers] Two simple questions
Date: 10/9/2003 5:32 PM

Dear all,

I have 2 questions I hope somebody can help me with:

- I am trying to do some simulations and need to fix a parameter to a
value greater than 999999 (which seems to be the maximum value in NONMEM). Is
there any way of getting around this limit?

- AMD has now introduced a new generation of processors for ordinary desktop,
Athlon 64. This processor can handle data in chunks of 64 instead 32. This
processor is also able to take advantage of higher RAM. Machines with Athlon
64 can still run programs written for the 32 bit chips. Will NONMEM (Fortran?)
be faster under this new processor type?

Thanks!

Toufigh Gordi 
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From: j.loetsch@em.uni-frankfurt.de
Subject: Re: [NMusers] Two simple questions 
Date: 10/9/2003 6:09 PM

Dear Toufigh 

About the AMD Athlon 64 let me know if you find out.
About the paramter, let it be XY, try something like that:
...
XY=THETA(1)*999999
...
$THETA 
999999 FIX

This makes your XY equal to 999999*999999. NONMEM output says that XY is
1.0000E+13. 
By such way, you should be able to get whatever paramter value you need.
Regards
Jorn

______________________________________________________
Jorn Lotsch, MD, PhD
pharmazentrum frankfurt, Institute of Clinical Pharmacology
Johann Wolfgang Goethe-University Hospital
Theodor-Stern-Kai 7
D-60590 Frankfurt am Main
GERMANY
Tel.:+49-69-6301-4589
Fax.:+49-69-6301-7636
http://www.klinik.uni-frankfurt.de/zpharm/klin/

_______________________________________________________

From: n.holford@auckland.ac.nz
Subject: Re: [NMusers] Two simple questions 
Date: 10/9/2003 6:12 PM


>> 
>> I have 2 questions I hope somebody can help me with:
>> 
>> - I am trying to do some simulations and need to fix a parameter to a value
>> greater than 999999 (which seems to be the maximum value in NONMEM). Is
>> there any way of getting around this limit?
>>


$THETA 1 ; BIG / 1.0D10

$PK

BIG = 1.0D10 * THETA(1)

CL=BIG*EXP(ETA(1)

 

>> - AMD has now introduced a new generation of processors for ordinary
>> desktop, Athlon 64. This processor can handle data in chunks of 64 instead
>> 32. This processor is also able to take advantage of higher RAM. Machines
>> with Athlon 64 can still run programs written for the 32 bit chips. Will
>> NONMEM (Fortran?) be faster under this new processor type?
>>


NONMEM will probably not care (but who knows the gremlins that may lurk inside that
assume certain word sizes?). The critical thing will be the compiler. If you can find
a compiler that generates code for 64 bit AMD then NONMEM should be able to use it. The
only 64 bit f77 compiler I know of is the Intel compiler but I think it only targets
the Itanium 64 bit Intel CPUs (not surprisingly). Whether 64 bit is faster than 32 bit
is a matter for experiment. 

--
Nick Holford, Dept Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556
http://www.health.auckland.ac.nz/pharmacology/staff/nholford/

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