From: "WANG,YANING" yaning@ufl.edu
Subject: [NMusers] Forrtl: error(72): floating overflow?
Date: 10/22/2003 1:03 PM

Dear users:
Could anyone suggest me some possible reasons for the following error to occur?
forrtl: error (72): floating overflow
Image              PC        Routine            Line        Source
ANIH2.exe          0040163D  Unknown               Unknown  Unknown
ANIH2.exe          0040706C  Unknown               Unknown  Unknown
ANIH2.exe          004727E3  Unknown               Unknown  Unknown
ANIH2.exe          00474DC2  Unknown               Unknown  Unknown
ANIH2.exe          0043BA46  Unknown               Unknown  Unknown
ANIH2.exe          0045920F  Unknown               Unknown  Unknown
ANIH2.exe          004640F9  Unknown               Unknown  Unknown
ANIH2.exe          0042A390  Unknown               Unknown  Unknown
ANIH2.exe          0042090E  Unknown               Unknown  Unknown
ANIH2.exe          004CBB09  Unknown               Unknown  Unknown
ANIH2.exe          004BDF24  Unknown               Unknown  Unknown
KERNEL32.dll       7C4E87F5  Unknown               Unknown  Unknown

With the exact same model and data, I got very good estimates (see below) for all the
parameters and SEs if FO is used. Once I switched to FOCE with interaction, this error
will show up and stop the fitting. Even after I put IF (ABS(ETA(1)).GT.10) EXIT 1 100
IF (ABS(ETA(2)).GT.10) EXIT 1 200
IF (ABS(ETA(3)).GT.10) EXIT 1 300
IF (ABS(ETA(4)).GT.10) EXIT 1 400
in my $PK block, the error messages still persist.

FO results:
THETA:      CL-L/h      V1-L        Q-L/h       V2-L
ETA:        CL[P]       V1[P]       Q[P]        V2[P]
ERR:        [P]         [A]
ANIH1.lst       -5494.555       eval=320 sig=+3.4 sub=95 obs=2536 CCIL=NNNN NV1.
1 PIV1.1
THETA     = 0.884       18.3        7.32        15.8
ETASD     = 0.186011    0.279106    0.392428    0.185742
ERRSD     = 0.104403    0.0519615
THETA:se% = 2.3         3.7         9.2         3.0
OMEGA:se% = 13.9        20.5        22.7        33.0
SIGMA:se% = 9.3         23.9

MINIMIZATION SUCCESSFUL

  user 0:28.75 real 0:28.75    tcl 0:0.78

Thanks for any input.

Yaning 
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From: "Bhattaram, Atul" BhattaramA@cder.fda.gov
Subject: RE: [NMusers] Forrtl: error(72): floating overflow?
Date: 10/22/2003 2:56 PM

Hello Yaning

You may want to check the lower bounds of the thetas and use exit statements
for CL and V.

Venkatesh Atul Bhattaram
CDER, FDA.


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