From: "Bonate, Peter" pbonate@ilexonc.com
Subject: [NMusers] Most important papers in PopPK 
Date: Thu, October 28, 2004 3:34 pm

Hi, everyone.  I am putting together a review manuscript on the
most influential papers on Pop PK-PD.  I'd like to get other
people's opinion on what they think those papers are.  If you
wouldn't mind I'd appreciate it if you sent a note indicating
what you think are the most important papers in our field.

This should generate a lot of traffic and should be fun. 

Thanks everyone, 

Pete 



Peter L. Bonate, PhD, FCP 
Director, Pharmacokinetics 
ILEX Oncology 
4545 Horizon Hill Blvd 
San Antonio, TX  78229 
phone: 210-949-8662 
fax: 210-949-8219 
email: pbonate@ilexonc.com 
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From: "Sarath Kanekal" SKanekal@Salmedix.com
Subject: RE: [NMusers] Most important papers in PopPK 
Date: Tue, November 2, 2004 1:26 pm 

Dear Peter,

A great and a timely idea, I have not seen a recent
comprehensive review of Pop PK/PD. The FDA guidance doc on
Pop PK (1999) contains a list of references,
http://www.fda.gov/cder/guidance/1852fnl.pdf;
many may still be relevant.

It would be very useful to industry folks if your review also covers
current regulatory guidance/requirements on PK/PD for drug approval. 

Sarath 

Sarath Kanekal, BVSc, PhD

Diplomate, American Board of Toxicology
Director, Pharmacology and Toxicology
Salmedix
9380 Judicial Drive
San Diego, CA 92121
Phone: 858 622 4973
Fax: 858 622 6675
e-mail: skanekal@salmedix.com
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