ADVAN5 Problem

NONMEM Topic 15

Keywords: ADVAN5, Numerical Difficulties, VAX VMS

Topic started by: jbf@cognigencorp.com (Jill Fiedler-Kelly) - 29 Mar 94

We recently ran into some difficulty running ADVAN5 with a simple
two compartment model. This data terminates successfully under ADVAN4.
The error message we consistently get, although with different ID
numbers depending on the initial estimates, is 'NUMERICAL DIFFICULTIES
OBTAINING THE SOLUTION'.
Data simulated (at the same time points as the original file) with 
ADVAN4 also terminate in the same error running under ADVAN5.

I was wondering if anyone else has had similar experiences or knows
if there is any reason to expect that this might happen?

Thanks for any help you can provide.
 
See topic 17


End of Topic - 14 Apr 94