Creating a New Pharma R&D Ecosystem


Pioneering Pharma of the Future℠ .

Do you feel that? It’s the industry changing. And no one has a finger on the pulse of drug development like our fearless leader Ted Grasela. So we thought, hey, let’s give him an outlet to share his wisdom. And so the Cognigen blog was born. Check back here often for insightful articles, unique views on industry trends, and a whole lot more on the evolution of this critical field.

November 30, 2012

The worst job in Pharma.

The job of Team Leader of an R&D team might not be as bad as being a Fish Squeezer or Deadly Snake Handler, but I nominate it as the worst job in Pharma.


October 1, 2012

Excellence is a team sport.

Excellence in pharmacometric modeling and simulation has to encompass 3 types of excellence: strategic, operational, and technical.


September 19, 2012

Modeling as a framework for knowledge synthesis.

Cross-functional, interdisciplinary knowledge synthesis is lacking in many development programs.


September 6, 2012

Mind the gap.

Why do you need a gap analysis? Because one thing is certain. The sooner you find the gaps and fill them, the better.


May 25, 2011

Innovation at the intersection of creativity and automation.

In the same way that the guillotine concentrates the senses, the need to improve productivity in the pharmaceutical industry has become a life-or-death imperative.


April 28, 2011

Why don’t computer systems help me as much as I think they should?

Complete and clear requirements are a critical element in the successful design and execution of workflows for pharmacometric analyses.


April 14, 2011

Scientific workflows—the knowledge-generating engines of R&D.

The interdisciplinary collaboration needed to specify workflow requirements, to achieve consensus on study methods, and to detail how to interpret and present results is surely the most critical step for improving productivity in the Pharma of the Future?.


March 30, 2011

Productivity is not a four-letter word.

On that global stage called “The Pharmaceutical Industry,” one of the dramas unfolding is the urgency to improve productivity at all levels—industry, team, and individual.


November 2, 2010

You WILL innovate!

Innovation is something that comes from a mysterious creative force that strikes like lightning to the fortunate inventor—or is it?


September 15, 2010

But. . .my projects are special.

To be successful, interdisciplinary R&D needs a conceptual synthesis to bridge the disciplines and allow research results from one discipline to be applied to the questions of another. Disease-drug models can provide this conceptual synthesis.


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