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Re: [NMusers] cumulative AUC

From: Sam Liao <sliao_at_pharmaxresearch.com>
Date: Fri, 8 Nov 2019 14:26:40 -0800

Thanks for all your quick reply.

I tried to add one dummy record at the starting time of all subsequent
treatments to get cumulative AUC values to correct the cumulative AUC
after each treatment.

Best regards,

Sam Liao

On 11/8/2019 11:18 AM, Matthew Fidler wrote:
> Hi Sam,
>
> Leonid is correct, you have to turn it off and then back on again.
>
> https://nlmixrdevelopment.github.io/RxODE/articles/RxODE-event-types.html#turning-off-compartments
>
> shows a visual example.
>
> Matt.
>
> On Fri, Nov 8, 2019 at 1:12 PM Leonid Gibiansky
> <lgibiansky_at_quantpharm.com <mailto:lgibiansky_at_quantpharm.com>> wrote:
>
> actually CMT=-4 turns compartment 4 off. It need to be turned on
> again,
> see by the record with CMT=4 (positive), see
>
> Plasma urine example
>
> in Nonmem help
>
> Leonid
>
> On 11/8/2019 1:47 PM, Leonid Gibiansky wrote:
> > Negative CMT (in the data set) resets compartment amounts
> (CMT=-4 in
> > this case)
> > EVID = 4 resets all system, including A(4)  (if washout time was
> long
> > and all compartments can be set to 0)
> > Also, it is easy to do post-processing, subtracting Cycle 1 AUC
> from
> > Cycle 1-2 AUC to get Cycle 2 AUC, etc.
> > Hope this helps
> > Leonid
> >
> > On 11/8/2019 12:59 PM, Sam Liao wrote:
> >> Dear nmusers,
> >>
> >> I have a question how to reset cumulative AUC in a $DES model,
> where
> >> DADT(4) is set up as cumulative AUC of C1.
> >>
> >> Because the study is a four way crossover study, the cumulative
> value
> >> of A(4) need to rest to zero before each subsequent treatments.
> >>
> >> However, NONMEM do not allow setting A(4) to zero in the
> statement of
> >> control stream.
> >>
> >> Is there any work around of this problem?
> >>
> >> Best regards,
> >>
> >> Sam Liao
> >>
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> >> --
> >> Sam Liao
> >>
>
--
Sam Liao



Received on Fri Nov 08 2019 - 17:26:40 EST

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