From: "bvatul" <>
Subject: IV and oral code
Date: Fri, 5 Oct 2001 15:32:01 -0400

Hello All
Has anybody analysed IV and ORAL pharmacokinetics simultaneously in NONMEM? Could you please let me know a few details about the code?

Venkatesh Atul Bhattaram
Post-doctoral fellow
University of Florida





From: (Joern Loetsch)
Subject: Re: IV and oral code
Date: Sat, 6 Oct 2001 22:17:07 +0200

Hi Atul,
this is not difficult.
Just take ADVAN6, write your model as usual, and put a depot compartment for the oral administration. I the data file, you have at the dosing record just to state where the dose goes. That is, in the central compartemtn in case of iv, in the depot compatemtn in case of oral.