From: Paul Hutson <firstname.lastname@example.org>
Date: Wed, 15 Aug 2001 14:50:41 -0500
I am seeking to simulate AUC-response relationships using $PRED, but
without $PK, since there are no TIME points involved. After generating the
simulated AUC-response (AUC, Effect) data, I would then evaluate them in
one of two effect data analysis models.
Several issues are confusing me:
1. In the SIMULATION 2 EXAMPLE, the generated table is described as having
the "concatenated output of all the subproblems...". what does this mean,
since I usually consider concatenation in FORTRAN to be a merging of
strings? Are the DV or other simulated values in the TABLE some form of
aggregate of the 10 repetitions? If not, where did the DVs from the
2. What are the advantages of using SUBPROBLEMS=x as opposed to providing
dummy "patient" IDs of 1..X?
Thanks very much.
Paul Hutson, Pharm.D.
Associate Professor (CHS)
UW School of Pharmacy
NOTE NEW ADDRESS effective 6/2001
777 Highland Avenue
Madison, WI 53705-2222
Tel: (608) 263-2496
FAX: (608) 265-5421
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From: Nick Holford <email@example.com>
Subject: Re: $SIMULATION
Date: Thu, 16 Aug 2001 08:23:56 +1200
Concatenated literally means chained together. With NONMEM this means:
results of subproblem 1
results of subproblem 2
Advantage of using SUBPROBLEM is that you can easily select the number of replications without having to change the original data file template.
Bottom line, just try it and look at the TABLE output...
Nick Holford, Divn Pharmacology & Clinical Pharmacology
University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
email:firstname.lastname@example.org tel:+64(9)373-7599x6730 fax:373-7556