From: Pascal Girard <>
Subject: Population compliance model
Date: Mon, 28 Dec 1998 16:04:56 +0100

Dear NONMEM users,

In the NONMEM repository, I have placed a NONMEM example for the implementation of a population compliance model; applied to the time of openings of an electronic drug container.

The full model is described in the recently published paper:

Girard, P., Blaschke, T.F., Kastrissios, H., and Sheiner, L.B. A Markov mixed effect regression model for drug compliance. Statistics in Medicine 17:2313-2334, 1998.

The address of the repository is :

The directory contains NONMEM codes and results as well as simulated data. If you are interested, please visit!

Best wishes and happy new year,

Pascal Girard

Service Pharmacologie Clinique
BP 3041,162, avenue Lacassagne
69394 LYON Cedex 03 FRANCE
Tel : +33 4 78 78 57 26
Fax : +33 4 78 78 57 19