From: "Sreenivasa Rao Vanapalli" <>
Subject: Multiple Doses
Date: Wed, 9 May 2001 09:54:25 -0500


I have some data obtained after a single and multiple oral administration. I found in the data that after 1st dose plasma concentrations decline substantially in subsequent administrations. The plasma concentrations decline almost 50% from 1st dose to sixth dose. I'm trying to model this data (two compartment). But I'm not sure how to incorporate this information into model. Any suggestions?

Sreenivasa Rao Vanapalli, Ph.D,
Janssen Postdoctoral Research Scholar,
S411 PHAR, College of Pharmacy,
University of Iowa, Iowa City, IA-52242
319-353-5157 (Office)
319-337-2687 (Home)