From: "bvatul" <>
Subject: Feed-back PK-PD models
Date: Tue, 25 Sep 2001 15:18:15 -0400

Hello All

Could somebody suggest me some references which have PK-PD modeling
based on feed-back mechanisms. i.e., say we have two markers A and B and
the levels of A are dependent on the levels of B (based on physiological
mechanism). The drug has an effect on marker A.

Thanks in advance


Venkatesh Atul Bhattaram
Post-doctoral fellow
University of Florida






From: "Piotrovskij, Vladimir [JanBe]" <>
Subject: RE: Feed-back PK-PD models
Date: Wed, 26 Sep 2001 08:58:48 +0200

The latest edition of the book by Gabrielsson and Weiner is a good source of
information about the feedback models.

Best regards,
Vladimir Piotrovsky, Ph.D.
Research Fellow
Advanced Modelling and Simulations
Global Clinical Pharmacokinetics and Clinical Pharmacology (ext. 5463)
Janssen Research Foundation
B-2340 Beerse