From: "jiang zhigang" jiangzhigangchn@hotmail.com Subject: [NMusers] Hi,dear all ,some new questions occur ! Date: Fri, 11 Aug 2006 13:26:34 +0800 Dear all, I appreciate your warmhearted help! Now,I have some new problems which are easy to you! Please help me ! When I read the NONMEM User Guide,I was puzzled by these matters: 1. In the book,there are many index plots. Now,I notice there are many characters(such as K,B,C,A,E,etc.) and numbers(such as 2,3,6,9,etc.) appears in the index plots! The approximate delineation as follow: AMT VS. ID ...................................................................................... . . 5 K * * . 3 B . 3A * . 3 A * . 6CB * * . 3 C * . 86C * * * . In addition,I don't understand why there are some characters such as G,F,H in the Index plot for weight(WT)?And,what's the meaning of them? What's the meaning of 3 or 2 in the plot of DV VS. ID? 2.The guide said:"Many points lie along the line AMT=0,where one sees integers 5,3,3,6,etc,as one proceeds along the ID axis,each integer indicating the corresponding number of points over-plotted at that location." My question is why there are so many overlap points in the index plot for AMT VS. ID?The picture' x-axis is AMT and its y-axis is ID,and the dot is corresponding to x-coordinate(AMT) and its y-coordinate(ID),so how does the points over-plotted ? Thank you very much! Best Regards Jiang _______________________________________________________ From: Mark Sale - Next Level Solutions mark@nextlevelsolns.com Subject: RE: [NMusers] Hi,dear all ,some new questions occur ! Date: Fri, 11 Aug 2006 03:38:29 -0700 Jiang 1.First, there are better plotting tools available than the built in plots in NONMEM (which are set up for 135 column UNIX text output, and upside down and backwards. Try Xpose (if you have/use S or R), http://xpose.sourceforge.net/ or NMGraphics (http://www.nextlevelsolns.com/downloads.html), which is an Excel macro. Both are free. A "2" means that 2 points are essentially superimposed. after you get to 9 points superimposed, an "A" means that 10 points are essentially superimposed, "B" means 11 points superimposed etc. 2. Each point is one observation at that AMT/ID. Obviously, the ID repeat (many observations for each person). For an observation record, the AMT = 0 - there was no dose for that record (it wasn't a dose, it was an observation, therefore, NONMEM considers the dose to be 0). Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com _______________________________________________________