From: Tomas Martin-Jimenez <>
Subject: Interspecies scaling
Date: 22 Aug 1997 16:55:10 -0400

Dear NM users:

We are trying to conduct an interspecies scaling analysis with NONMEM for plasma and tissue levels with several drugs. We aim to be able to extrapolate pharmacokinetic parameters and predict plasma and tissue levels across species for a certain dose.

I have been searching for references but I haven't found much. Is anybody aware of publications dealing with the application of mixed effects modeling to interspecies scaling of PK parameters.

On the other hand, I would appreciate your suggestions on modeling strategies to conduct an study like this using NONMEM.

Thanks much.

Tomas Martin
Tomas Martin-Jimenez, DVM
FARAD East Regional Center
North Carolina State University
College of Veterinary Medicine
4700 Hillsborough St
Raleigh NC 27606
Ph: (919) 821-9519, 829-4398
Fax: (919) 829-4358