From: "Stephen Duffull" <>
Subject: What does "CENTERING" do?
Date: Sun, 27 Aug 2000 11:58:45 +0100

Hi All

Can anyone please explain to me what "CENTERING" as a term in $ESTIMATION does? I have used it and can appreciate the results. I have read the manual which states that "Centering requests the average conditional estimate of each eta to be constrained to be close to zero", but what does it actually do within NONMEM - how does it do this?

Any info would be appreciated.


Stephen Duffull
School of Pharmacy
University of Manchester
Manchester, M13 9PL, UK
Ph +44 161 275 2355
Fax +44 161 275 2396






Date: Fri, 27 Aug 1999 08:42:37 -0700 (PDT)
From: ABoeckmann <>
Subject: Re: What does "CENTERING" do?

Please look at Guide VII Conditional Estimation Methods, March 1998. The method is defined on p. 7. Pages 13-14 should also be read carefully.

Alison Boeckmann