From: "Piotrovskij, Vladimir" <>
Subject: Survival analysis in NONMEM
Date: 14 Jan 1998 03:18:09 -0500

Dear NONMEM users,

Has anybody of you an experience in implementing the survival analysis, particularly, Cox proportional hazard and related models? If yes could you share it with the list?



From: lewis@c255.ucsf.EDU (LSheiner)
Subject: time_to_event
Date: 22 Jan 1998 15:44:23 -0500

Responding to the emails reproduced below, I have modified the old LOGIST.DIR in NONMEM.DIR at (IP address as follows.

I have

1. Changed the name of LOGIST.DIR to NON_CONTINUOUS.DIR

2. Modified README.009

2. Added a control stream fora Weibull-type time-to-event model

The time-to-event code has the limitation that it does not deal with continuously time varying hazard. This is something that, as I said in my original note, I am still working on, and I hope to add a control stream for this in the near future.

From Thu Jan 15 07:19:10 1998
Dear NONMEM Users,

It seems to me that the example Lew gave is dealing with a class of survival models called multiplicative intensity models and do not necessarily extend to mixed effect modeling. To my knowledge no marketed software is available for this type of modeling.

It would be rather exciting if some one could develop these models in NONMEM, though I still maintain that the NONMEM software is not necessarily the most efficient or practical place for these models.

The best reference for these models is Counting Processes and Survival Analysis by Thomas R. Fleming and David P. Harrington published by Wiley Interscience.

Darryl Penenberg
Assistant Director
Biometrics, Clinical Operations
Pfizer Pharmaceuticals


From: "Piotrovskij, Vladimir" <>
Subject: RE: Survival analysis in NONMEM
Date: Thu, 15 Jan 1998 09:07:00 +0100

Dear Lew,

Thanks for your reply. I wonder how did you implement a mixed effect survival model in NONMEM. If your analysis is published, could you provide me with a reference? If it isn't could you, please, share your code with me?

Thanks in advance,