From: Christoffer Tornoe <>
Subject: [NMusers] nlmeODE package combining NLME with a differential equation solve
Date: 7/7/2003 4:05 AM

Dear All 

A new non-linear mixed-effects modelling package for R called nlmeODE is now
available at and

It combines Pinheiro and Bates' NLME library in R with an ordinary
differential equations (ODE) solver thereby enabling the use of differential
equations in population PK/PD modelling. It includes several PK examples
such as one- and two-compartment models with multiple doses and infusions.

Best regards
Christoffer Wenzel Tornĝe
Ph.D. student
Clinical Pharmacology & Experimental Medicine Department
Ferring Pharmaceuticals A/S