From: "Bonate, Peter" 
Subject: [NMusers] When is PK not needed
Date:Wed, 11 Jun 2003 09:38:25 -0500

Hello, everyone.
I have a question to the collective conscious of the group that is sure to bring out some
interesting discussion.  In clinical studies, particularly in Phase 3, when it is NOT
necessary to collect PK information.  Basically, when is enough enough?  This question goes
right to the heart of why do we collect PK in the first place.  Any thoughts on this would
be appreciated.

Thank you in advance,


Peter L. Bonate, PhD, FCP
Director, Pharmacokinetics
ILEX Oncology, Inc
4545 Horizon Hill Blvd
San Antonio, TX  78229
phone: 210-949-8662
fax: 210-949-8487