Subject: [NMusers] NONMEM mathematical background 
Date:  Mon, June 13, 2005 12:33 pm 
Dear NM users

Brand new to NONMEM, I'm looking for litterature references about the
mathematical and statistical part behind NONMEM.
French statistician PhD student, I'm looking for information about both :
1. the way to estimate the parameters and
2. optimal experimental design,
in the very case treated by NONMEM, i.e. systems of nonlinear differential
equations _which have no closed form solution.

Any help much appreciated,
Thank you very much for having read this e-mail !

Julien Cornebise,
University Pierre et Marie Curie (Paris 6)

Groupe E.S.I.E.A.