From: Ramalingam Sankaran sankaram@Stanford.Edu
Subject: [NMusers] Estimation Methods-HELP!!  
Date: Fri, March 19, 2004 10:42 am  

Dear All:
I wonder if any of you could suggest a publication or a text-book that 
would help someone WITHOUT much math. background,to understand the 
estimation methods(the first order, FOCE, hybrid etc.,).The Users guide 
seem a little daunting, and my search for a basic work to understand the 
concept and applications has not been fruitful.
Will be grtaeful for any sugesstions.
Thanks a lot


From: Bhattaram, Atul
Subject: RE: [NMusers] Estimation Methods-HELP!!  
Date: Fri, March 19, 2004 10:51 am  

Hello Ram

In my experience to understand the estimation methods etc it is better to
start with fundamentals on probability theory, regression. To understand the
Maximum likelhood principles etc I would recommend you to attend statistics
courses in your university.

Venkatesh Atul Bhattaram


From: Howard Lee
Subject: RE: [NMusers] Estimation Methods-HELP!!  
Date: Fri, March 19, 2004 11:07 am  

Dear Ram,

I found the following book very useful.

Rice,J.A., Mathematical Statistics and Data Analysis, Duxbury Press, 1995,
ISBN (0-534-20934-3)

Hope this helps. Thank you.

Howard Lee, MD, PhD

Assistant Professor
Center for Drug Development Science
Department of Pharmacology, Georgetown University
School of Medicine, Box 571441
Washington, DC 20057-1441
Tel: 202-687-8198
Fax: 202-687-0193



From: Wang, Yaning
Subject: RE: [NMusers] Estimation Methods-HELP!!  
Date: Fri, March 19, 2004 11:25 am  

The following book is an excellent resource after you learn enough
"Nonlinear Models for Repeated Measurement Data" by Marie Davidian and David
M. Giltinan, Chapman & Hall, ISBN 0-412-98431-9

Yaning Wang



From: Melvin S. Munsaka, PhD
Subject: RE: [NMusers] Estimation Methods-HELP!!  
Date: Fri, March 19, 2004 12:59 pm

The following documents may also be useful. Unfortunately, I cannot promise "WITHOUT
much math"
as requested by Ram. I think the math cannot be avoided.
Melvin S. Munsaka, PhD
Senior Statistician
Takeda Global Research and Development Center, Inc
Biometrics and Data Management, Statistics Dept
475 Half Day Road
Lincolnshire, IL 60069
Phone (Direct): 847-383-7390
Phone (Toll Free): 877-872-3700 x 7390
Fax (Business): 847-383-3501



From: Bachman, William (MYD)
Subject: RE: [NMusers] Estimation Methods-HELP!!  
Date: Mon, March 22, 2004 9:28 am 

I would recommend first reading the FDA Guidelines for population analysis
(free off the web).  Getting a bit dated but it's a good overview of the
topic and the references are the seminal historical papers in the field.  If
you don't like math, this is not the best area to work in.

I would also recommend putting a subject on your emails.  Many people often
assume an email without a topic is spam and auto-delete it.


From: Vladimir Piotrovsky, Ph.D.
Subject: RE: [NMusers] Estimation Methods-HELP!!  
Date: Mon, March 22, 2004 11:45 am  


I recommend two textbooks:

Vonesh EF and Chinchilli VM. Linear and nonlinear models for the analysis of
repeated measurements. Marcell Dekker, 1996. ISBN 0-8247-8248-8

Pinheiro JC and Bates DM. Mixed-effects in S and S-PLUS. Springer, 2000.
ISBN 0-387-98957-9

The first one is somewhat similar to Davidian and Guiltinan's book, but
gives a good math and stat introduction useful for a novice. Although
Pinheiro and Bates' book is about S language and has no relation to NONMEM,
it is useful to understand e.g.  hypothesis testing associated with
mixed-effects modeling.

Best regards,


Vladimir Piotrovsky, Ph.D.
Research Fellow, Advanced PK-PD Modeling & Simulation
Global Clinical Pharmacokinetics and Clinical Pharmacology 
Johnson & Johnson Pharmaceutical Research & Development
Turnhoutseweg 30 
B-2340 Beerse